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KMID : 0361520010120040322
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Korean Journal of Psychopharmacology
2001 Volume.12 No. 4 p.322 ~ p.327
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Effect of Ketamine on the Echoic Memory Process : The Mismatch Negativity and Glutamate Receptor System in Schizophrenia
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윤탁/Tak Youn
안경흡/배지수/김명선/김재진/권준수/Kyung Heup Ahn/Ji Soo Pae/Myung Sun Kim/Jae Jin Kim/Jun Soo Kwon
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Abstract
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Objective: The abnormality of mismatch negative (MMN) in schizophrenia is thought to be associated with perceptional disturbance and cognitive dysfunction. And the antagonists of the N-methyl-D-aspartate (NMDA) receptors, ketamine, can
induce
anomalies of psychophysiology and cognitive function as those of schizophrenia. In order to explore the role of NMDA receptors on echoic memory system, MMN under ketamine administration was analyzed. Methods: MMNs of Healthy 12 subjects
under
subanesthetic dose (0.65 ㎎/㎏/hr) of ketamine administration in placebo-controlled design were recorded by 128 channel EEG. Brief Psychiatric Rating Scale (BPRS) change was also evaluated. Results: BPRS score was significantly increased
by
ketamine administration (t=-6.655, p<0.005). Ketamine induced significant decrease in MMN amplitudes (Fz, t=-2.572, p=0.026). Neither MMN amplitude under placebo administration nor MMN latencies under ketamine administration and placebo was
changed
significantly. Conclusion: Ketamine induced echoic memory dysfunction in healthy subjects, which is usually found in schizophrenic patients. Consequently, reduced glutamatergic activity in brain could be involved some early processes of
the
memory dysfunction in schizophrenia.
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KEYWORD
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